Rice production is a key livelihood for more than 80% Vietnam rural population. Recently, it leads Vietnam to become one of emerging growth economies in the Asian Pacific and the world third largest rice exporter. Of which, there are more than 90% of exported rice quantity are come from the Mekong Delta of Vietnam. This sector, however, is facing challenges generated by global issues such as climate change impacts, land degradation and environmental pollution. On top of this, there are other internal challenges that rice farmers in the Mekong Delta has faced due to direct impacts of sea level rise and indirect impacts of upstream development. As a result, saline intrusion and fresh water shortage for rice irrigation in dry season is emerging research issues. This paper presents a water saving technique in rice production using Alternate Wetting and Drying (AWD) model in saline intrusion and fresh water scarcity areas in the Mekong Delta. Study results show that AWD technique helps farmers save more than 50% of irrigated water in the wet season, compared to control technique. Similarly, in the dry season, AWD technique reduced 30 % of irrigated water that could be stored and be used for rice in duration of 10-15 days under saline instruction and fresh water shortage conditions. Moreover, AWD technique reduces chemical fertilizers, pesticides, and gives more rice yield, net income, investment efficiency compared to normal rice practice. Over two rice cropping seasons, more than 50% of rice farmers in the commune where the study undertaken, have leant and wanted to apply the AWD technique. In conclusion, AWD is an adaptive technique in rice production dealing with saline and water shortage conditions. It not only helps farmers overcome hard environmental conditions in rice production, it also improves rice yield, reduces production costs of rice and therefore increase net income for rice farmers. This technique needs to be extended and diffused to rice community in order water resources are used effectively.