Asian red-tailed catfish (Hemibagrus wyckioides Fang & Chaux, 1949) reared in cage culture was studied in An Giang province, the upstream region of the Mekong Delta, Vietnam. The aim is to identify technical aspects, financial aspects and analyze the cage owners’ advantages and disadvantages. The study was carried out on the cage systems on the main and the branch rivers within the province from June to December 2022 by surveying 60 households. Results found that each household has 1-5 cages, the volume of each cage is 90-120 m3, and the cage volumes per household were classified into 3 groups: small group (S-group) < 100 m3 household-1, medium group (M-group): > 100-500 m3 household-1, and large group (L-group) > 500 m3 household-1. The culture period was 16±2 month harvest-1. The price of the marketable fish was 2.5-3.5 USD kg-1. The profit was from 25 -73.2 USD m-3 ,but over 50 % of households had losses and no profits. Feeding accounts for 70-80 % of total costs. The households in the L-group often stock larger fingerling, but the density stocking was the lowest with 53.4±32.7 ind m-3, and the yield was 29.3±18.0 kg m-3. The yield of the cages in the main rivers was higher than in the branch rivers