In the context of the ongoing implementation of the general education program, especially in primary education, effectively managing the development of high school teaching staff is crucial for achieving comprehensive educational reforms. This study focuses on the current state of development of teaching staff in high schools in Ninh Kieu District, Can Tho City, Vietnam and aims to identify the challenges, advantages, and influencing factors. The study was conducted using a survey from a questionnaire of 216 respondents, including school managers and teachers of 03 high schools in Can Tho City, including An Khanh, Chau Van Liem, and Nguyen Viet Hong. Various obstacles hinder the effective development of teaching staff, namely resource limitations, inadequate training programs, and insufficient support mechanisms. Some suggested solutions might be implemented synchronously, considering specific conditions and timeframes. The prioritization of measures based on feasibility and impact is essential to maximize effectiveness. And the proposed measures aim to address various aspects of management and teaching staff, fostering an environment conducive to the development of high school teachers. By doing so, these measures will contribute to meeting the requirements of the 2018 General Education Program by the Vietnamese Education and Training, thereby enhancing the overall quality of education in Ninh Kieu District, Can Tho City as well.