This study examined the challenges of self-studying English-speaking skills for first-year English studies majors at Can Tho University. The study aimed to answer questions such as: What self-study strategies can first-year students majoring in high-quality English at School of Foreign Languages at Can Tho University apply to develop speaking skills? The target audience was 96 English studies majors who have studied speaking and listening at Can Tho University. A questionnaire and an interview with 13 students were used to collect data for this study. In order to support the quantitative data, a questionnaire was used, while an interview was used for the qualitative data. This study aimed to find out the difficulties encountered by students, thereby proposing solutions to overcome them and improve the quality of their learning autonomy or self-studying English-speaking skills.