Potential effects of the teamwork and employee performance have been identified in the literature and viewed as as one of the most concerns in a branch of the human resource management (HRM). The study aims to examine effects of the teamwork on employee performance basing upon a survey from 120 employees working for 2 to 5 star-ranked hotels in Can Tho city. The widely-used methods for the qualitative data analysis including the Exploratory Factor Analysis (EFA) and regression analysis were applied. The empirical results show that the employee performance is positively and directly related with four elements, relevant to the postulated theory. It is also worth noting that two out of these four factors - Recognition and reward and Team trust – are enough of the statistical significance which may explain in the relation with the employee performance at hotels. In conclusion, some main findings and limitations of the study are pointed out.