Because of its healthful nutritional properties, pomelo is gaining traction in the food and beverage industry. Pomelo juice concentration as a beverage provides vitamins, antioxidants, and energy. The Design Expert 11 calculation software is used to optimize the concentration process parameters, the temperature range is determined to include ± a values converted as axial. The results showed a positive correlation between the two factor variables and the obtained target function (TPC), the optimal value for the selected procedure was based on 79 °C with a time of more than 1.78 hours. At this point, TPC retention is 71.121%.