The Mekong Delta has a system of interlaced canals together with mountains, forests, and islands that form a diverse ecological region. The landscapes are not only wild and majestic but also plain and mysterious. This is the tourism industry’s potential and advantage, especially the tourism associated with the river lives in the Southwest region. However, the tourism industry in the Mekong Delta is facing limitations and challenges from within. As a result, this restricts the tourism that has a lot of "great rooms" for development. This study focuses on evaluating tourism limitations, thereby proposing several solutions to develop the Mekong Delta’s tourism industry in the future.