This study investigated ecosystem services on the Hau River provinces (An Giang, Can Tho, Vinh Long, Soc Trang) of Mekong Delta of Vietnam. It is found that the river has directly and indirectly provided various regulation and support services. Moreover, the river is the place where many festivals and traditional beliefs activities take place featuring with different eco-tourism and experiential activities. However, hydrological changes, reduced river’s water quantity and quality, and riverrelated development policies have degraded the river’s ecosystem services. The change in water quality and quantity has been considered the main causes of ecosystem services changes. Therefore, action plans for the restoration, protection and sustainable development of river ecosystem services are needed.