Chemical constituents of Scoparia dulcis Linn growing in An Giang province were investigated. The result showed that four compounds, including 5,6,7,8,3',4'-hexamethoxyflavone (1), 5,7,8,4'-tetramethoxyflavone (2), 5,7-dihydroxy-6,8,3',4'-tetramethoxyflavone (3) and coixol (4) were isolated from the dichloromethane extract. In which, two methoxyl flavonoid  (1) and (2) were firstly isolated from this material. These structures were elucidated by modern spectroscopic methods as ESI-MS, 1D- and 2D-NMR and by comparsion to the published data. The study has been continued.