Plant nutrient management and environmental conditions significantly affect plant growth, development and antioxidant contents. This research aims to identify the most effective plant nutrient management and environ-mental conditions for enhancing high-antioxidant tomato production. The Sweet Girl and Ranger tomato cultivars were evaluated for yield, fruit quali-ty and antioxidant contents under 2 conditions: E1 (temperature ranging from 29 to 38 °C and relative humidity between 71–73 %) and E2 (temperature ranging from 32 to 36 °C and relative humidity between 75–80 %). These conditions were subjected to 6 different nutrient formulas, including Hoagland solution as control (H), H with 400 ppm potassium (H+K400), H with 300 ppm potassium (H+K300), H with 20 ppm nickel (H+Ni20), H with 10 ppm nickel (H+Ni10), H with 300 ppm potassium and 10 ppm nickel (H+K300+Ni10). The nutrient formulas did not yield signifi-cantly different results in terms of per-plant yields for the 2 cultivars. How-ever, the H+K400 treatment showed notably higher lycopene contents, with increases of 1.2-fold for Ranger and 1.24-fold for Sweet Girl cultivars. Addi-tionally, this treatment led to significant enhancements in total soluble sol-ids (TSS) and β-carotene content in the Sweet Girl cultivar, by 1.09-fold and 1.10-fold compared to the control respectively. Environment E2 provided more favorable conditions for achieving increased antioxidant tomato pro-duction, including improvements in fruit color index (red/yellow) by 1.11 to 1.18-fold, fruit firmness by 1.13 to 1.14-fold, TSS by 1.10 to 1.24-fold, lyco-pene by 1.98 to 2.45-fold and β-carotene by 3.29 to 5.68-fold. Therefore, the H+K400 nutrient treatment and/or the E2 greenhouse conditions are recom-mended for producing high-antioxidant tomatoes, which have significant potential for fresh consumption or as materials for the nutraceutical or food industry.