Humans’ healthcare demands have increasingly been high and require quality in medical examination, treatment and care. Therefore, health workforce training is required to ensure quality to meet those requirements. The graduates of health sciences must ensure the competencies that society needs. In training health sciences, clinical practice activities are considered the center of the training program. Clinical practice activities are considered a feature of medical training. In order for clinical practice activities to achieve the expected results, clinical practice activity management plays a decisive role in training, especially the clinical practice activities of students at universities of medicine and pharmacy. In order to improve the efficiency of management and enhance the quality of training at Can Tho University of Medicine and Pharmacy (CTUMP), Vietnam, the issue “Managing clinical practice activities of students at Can Tho University of Medicine and Pharmacy” was chosen for the research. The paper was carried out with the goal of researching the management of clinical practice activities of students at CTUMP to contribute to improving the quality of training in health sciences at the University, especially the quality of training in the clinical practice. Survey data was conducted on 370 participants belonging to four groups: managers, lecturers, medical staff and students. For the research results, the paper has systematized the theoretical basis for the activities, the management of clinical practice activities of students at CTUMP and the factors affecting the management of clinical practice activities of students. On that basis, the research surveyed the reality of activities and management of clinical practice activities of students at CTUMP. Through analyzing the survey results, the management of clinical practice activities of students at CTUMP is evaluated as quite good and there are many advantages. However, there are still some limited issues in managing students’ clinical practice activities. From those results, the study proposes some management measures to improve the limitations. In general, for clinical training activities to achieve results, scientifically managing clinical practice activities of students will contribute to enhancing the quality of students’ clinical practice, and increasing the quality of training the medical human resources at Can Tho University of Medicine and Pharmacy.