Vietnam, a Southeast Asian country, has documented 1,515 polymerase chain reaction-positive confirmed coronavirus disease 2019 (COVID-19) cases with 35 deaths a year after the first infection recorded in Ha Noi on January 23, 2020. Half of the infected patients are at the age of 21 to 40 y. While numbers of infections in many countries in the region continue to surge, Vietnam is seeing decreases in the number of daily new cases. As a result of COVID-19 trajectory different from the other countries, as of April 23, 2020, Vietnam is no longer under lockdown and is slowly restarting its socioeconomic activities. This report aims to provide a summary of the COVID-19 situation and response to the pandemic in Vietnam.