In the context of an integrated economy with many opportunities and challenges, especially the Coronavirus disease (Covid-19) is causing many difficulties for all nations of the world, entrepreneurship is seen as an effective method to handle social problems and create new values for the economy. Promoting entrepreneurship in the Mekong River Delta is an urgent issue that determines each locality's long-term economic development potential. This study explores the status quo of entrepreneurship in the Mekong River Delta (MRD). The data for this study comes from two sources. First, secondary data was collected from three main publishments: (1) The report of Global Entrepreneurship Monitoring (GEM) about Entrepreneurship index in Vietnam 2017/2018, (2) 2017 Survey of Entrepreneurs and MSMEs in Vietnam, and (3) research papers related to entrepreneurship in the MRD. Second, primary data comes from the survey results of 406 graduates from colleges and universities in the MRD. The data was presented by graphs and tables. There are five key findings. First, entrepreneurial models in the MRD are not really creative and innovative. A mmajority of their products are popular and old, only 22,4% are new products. Second, business activities in the start-up stage, 41.1% of business operations have less than 25% foreign customers. Third, there are 93.3% of start-ups expect to create more than 6 jobs for the market. Fourth, 86% of people started a business because there was no better job choice. Fifth, commercializing and transferring scientific research results of the MRD’s government to the enterprise were evaluated the best in the ecosystem.