The objective of this study is to identify factors affecting the profit of Nam Roi pomelo farmers in Binh Minh Town, Vinh Long Province. Data of the study were collected by direct interviews with 90 farmers planting Nam Roi pomelo in Binh Minh Town. By applying the multivariate linear regression, the research points out that Nam Roi pomelo planting models have brought high economic efficiency for farmers. The profit of Nam Roi pomelo farmers is influenced by the production area, fertilizer cost, pesticide cost, education level, and production experience of farmers. In which, the production area, education level, and production experience positively impact the profit of Nam Roi pomelo farmers in Binh Minh Town, Vinh Long Province