In this perspective research article, we present a different take on the emerging issue of in-situ resource utilization (ISRU) through proposing technology disruption as solution for the engineering complex space systems. At the example of space chemical manufacturing, we consider microfluidic approaches as prime tool to achieve process intensification. In particular, we propose a blue-sky vision how to develop circular chemical processes in space, how to integrate these, shield in space habitats and connect them to resources and markets via hubs. In the latter context, we pinpoint at the ‘Verbund strategy’, developed by the world’s largest chemical company BASF, to integrate space processes. On a related note, we identify requirements engineering as a tool to assist the development of complex space systems, which demands for teaming up many stakeholders. The trifold circle ‘Process-intensification/Circular-processes/Verbund-integration’ will be exemplified through own and literature microfluidic applications.