Background: Present work deals with the assessment of Physico-chemical parameters of water samples of Hau River in An Giang and Can Tho Provinces in Vietnam with six sampling sites each. This is because there has been increasing land use around Hau River in the recent past whose activities significantly affect water quality parameters, therefore, making it crucial to assess the water quality in these areas. Materials and methods: The water samples were collected and analyzed monthly from January to December 2019. The purpose of this study was to assess the water quality parameters along the Hau River to establish the possible setbacks associated with its deterioration and thus derive recommendations. A correlation matrix was used to determine Pearson’s correlation coefficient (r) value to identify the water quality parameters that were both highly correlated and interrelated. Differences in each pair of parameters were analyzed using multivariate means in Minitab software Version 19.2020.1.0. Results: The results parameters were compared with the desirable ranges for aquaculture as recommended by various authors. It was found that there was an appreciable significant positive correlation or Temperature vs Salinity at AG5 (r=0.611, p3-(r=0.617, p3- (r=-0.682, p43- (r=-0.641, p Conclusion: It can, therefore, be concluded that most of the water quality parameters in Hau River were within the desirable ranges for aquaculture except DO, which was slightly below while, on the other hand, BOD and Total Coliform were above the desirable ranges for aquaculture.