Climate change has seriously affected agriculture and many aspects of the life of local people in the Vietnam Mekong Delta (VMD). Learning to shift towards sustainable development to successfully adapt to climate change is essential. The VACB (V—garden/orchard; A—fishing farm; C—livestock farm; B—biogas) model is considered one of the best approaches and methods to adapt to climate change in the VMD. This paper aims to explore the transformative social learning and sustainable development associated with this model in terms of agricultural transformation for sustainability to climate change adaptation in the VMD. The mixed methods approach that guided the data collection included focus group discussions, in-depth interviews with key informants and household surveys. Our findings show that there are three learning processes associated with transformative social learning linked to the VACB model: instrumental, communicative and emancipatory learning. Farmers reported increased knowledge and improved relationships and efficiency when applying the VACB model using several learning channels, both formal and informal. Farmers highlighted six factors that influenced transformative social learning during the adoption and development of the VACB model and several barriers to implementing adaptation strategies to climate change in an attempt to upscale the VACB model.