Climate change is one of the challenges of human beings in the current time. Vietnam is one of the most heavily impacted countries in terms of climate change. Climate change has been remarkably increasing the vulnerability, threatening to be underdeveloped the development of society2. Soc Trang is one of the provinces in the Mekong Delta that is affected by climate change, mainly in coastal areas. The local people live mainly on the weather during time, due to climate change in recent years, the human’s daily life has been more difficult. People are greatly influenced by the transformation of the weather especially the elderly, women and children. The study aimed to analyze the impacts of climate change on the lives of people in Mo O, Tran De, Soc Trang. The study conducted in-depth interviews with 40 households living in the study area, with a descriptive statistical analysis method, showed the living conditions of local people in the study area including positive and negative aspects by the climate change, then proposed several feasible and effective solutions to adapt to climate change in order to ensure sustainable development and contribute to improve the human’s daily life of the local people.