The study assessed the growth and nutrient uptake capacity of Hymenachne acutigluma (Steud.) Gillilland by cultivating plants in striped catfish (Pangasianodon hypophthalmus) pond water for 42 days. The experiment simulated varying degrees of nutrient enhancement by using fish pond effluent enriched with three levels of nitrogen (N) (2.1, 4.3 and 8.6 mmol/l) and three concentrations levels of phosphorus (P) (0.16, 0.32 and 0.64 mmol/l) using NH4NO3 and KH2PO4, respectively. The treatments were arranged in a completely randomized design with four replications. Raw striped catfish pond water was served as background growth solution which was spiked with NH4NO3 (as a N source) and KH2PO4 (as a P source) and was renewed weekly. Nitrogen supply significantly affected most tested parameters whereas P only affected biomass, P content and N : P ratio content and accumulation in the roots and the shoots. H. acutigluma had significant higher growth, biomass and nutrient uptake when N concentration increased but not for the case of P increment. H. acutigluma helped to remove 7.6-19% N and 2.1-5.2% P from total input N and P concentrations in the experimental treatment. It indicates that Hymenachne appears to be a promising phytoremediation agent in nutrients removal from aquaculture water.