The particle size and morphology of levothyroxine sodium were investigated by GAS precipitation using dense carbon dioxide as the antisolvent and ethanol as the solvent. Experimental runs were carried out at 25 and 40 oC and pressures up to 110 bar. The effects of concentration of the organic solution on particle size and morphology were also investigated. The results show typical spherical nanoparticles and bimodal particle size distribution. Further studies should be done to take advantage of these characteristics in drug formulation and delivery systems.
Tạp chí: 2013 International Annual Meeting of the American Society of Biological and Agricultural Engineers (ASABE), July 21-24, 2013, Kansas City, Missouri, USA
Tạp chí: 2nd INTERNATIONAL FOOD SAFETY CONFERENCE (IFSAC) 2013, Food Safety: Critical Dimension of Food Security in Emerging Economies; Royale Chulan, Kuala Lumpur, Malaysia, December 2nd – 3rd, 2013
Tạp chí: 5th Symposium on Antimicrobial Resistance in Animals and the Environment ARAE 2013 Thời gian tổ chức: 30 JUNE – 3 JULY 2013 AULA Ghent, Belgium
Tạp chí khoa học Trường Đại học Cần Thơ
Lầu 4, Nhà Điều Hành, Khu II, đường 3/2, P. Xuân Khánh, Q. Ninh Kiều, TP. Cần Thơ
Điện thoại: (0292) 3 872 157; Email: tapchidhct@ctu.edu.vn
Chương trình chạy tốt nhất trên trình duyệt IE 9+ & FF 16+, độ phân giải màn hình 1024x768 trở lên