Vietnam has experienced multiple changes in its economy and job sectors. However, a gap persists in the research on trends of choosing job sectors after graduating from university. A survey was conducted on graduates of Can Tho University (CTU), a long-standing and prestigious university in the Mekong Delta, Southern Vietnam, to investigate trends in choosing and changing job sectors. The study of 22,659 CTU graduates reveals that the number of students in favour of working in the private economic sector tends to increase gradually over the years. In contrast, a decline has been observed in the number of students who prefer to work in state organisations, joint venture companies, or start their own business. This study enables education managers to modify strategies, build training programmes, intensify soft skills, and connect private enterprises to meet practical requirements.