The present work aims to synthesize bimetallic CuZn-ZIFs using a solvothermal method to degrade Basic Fuchsin in an aqueous solution in the presence of hydrogen peroxide (H2O2) under ambient conditions. Zn and Cu were loaded successfully on the ZIF structure due to the linkage of Cu–N and Zn-N found by FT-IR. The combination of Cu/Zn on the ZIF structure enhanced the specific surface area up to 1568.4 m² g⁻¹ and 0.48 cm³ g⁻¹ of pore volume, which can facilitate the performance of BF degradation. Under the optimum conditions, including a reaction time of 20 min, an initial BF concentration of 30 mg L⁻¹, and catalyst dosage of 0.1 g L⁻¹, H2O2 level of 0.03 mol L⁻¹, the efficiency degradation of BF achieved significantly high with above 96% through Fenton-like mechanism. CuZn-ZIFs also performed higher catalytic activity compared to some homogeneous and other heterogeneous catalysts. Notably, it was observed that the catalytic activity of CuZn-ZIFs mostly remained after five cycles. The study offers valuable insights into the utilization of novel materials for potential applications in pollutant treatment and environmental remediation.