This paper deals with Can Tho University (CTU), one of the most comprehensive public universities in the Mekong Delta region in the south of Vietnam, on the way to improve both the quantity and quality of the administrative officials after its 55 years of foundation and development. Enhancing CTU staff is an indispensable thing to meet increasingly modern requirements for the education reforms throughout Vietnam in the educational settings. This paper also presents the results of a survey in the forms of a questionnaire with open-ended interviews on the current state of the development of the administrative officials in CTU on the factors such as planning, recruitment, employment, training and fostering and building working environment and conditions for these staffs. Also, some suggested solutions will be posed to help CTU Board and college and school leaders to have reliable data on human resources development towards its high qualified staff.