Currently, medical waste in hospitals is an environmental issue that is of concern. This study investigates current status of generation and management of solid wastes at Can Tho City Central General Hospital. The results showed that the main composition of solid waste were domestic solid wastes accounting for 80%, hazardous wastes accounting for 16% and recycled wastes occupying 4%. From 2014 to 2018 the total amount of hospital solid wastes decreased by 465 tons. The amount of solid waste generated was not equal between months of the year, the highest in October (108,071 kg) and the lowest in February (54,285 kg). The average amount of solid waste generated per day is around 2,442 kg/day and the average amount of solid waste generated per day per patient bed is approximate 1.9 kg/bed/day. At the hospital, 100% of solid waste generated are sorted and collected. The classification is 100%, the collection and transportation reached 40% compared with the provisions of the Joint Circular No. 58/2015/TTLT-BYT-BTNMT. The hospital leaders need to strengthen solid waste management to ensure environmental sanitation in the hospital.