Rice-lotus rotation model includes one crop of rice and one crop of lotus cultivation in one year. After harvesting rice, the straw is buried in the soil to provide fertilizers for lotus seeds. After three months of growing, the farmers can harvest lotus products for three months. The rice-lotus rotation model is adaptive in the context of climate change in the Vietnam Mekong Delta. In particular, this model reduces pests and diseases, increasing soil fertility. The model also reduces the cost of rice cultivation, bringing economic and social benefits. In addition, the model also contributes to reducing the initial investment costs when cultivated conversion of crops. Farmers will take advantage of fertilizer usage for rice cultivation with this model because of the reserve of rich sludge in the topsoil from growing lotus. This model is also highly appreciated when dealing with dangerous diseases on the lotus. We conducted this study to evaluate the financial efficiency of the rice-lotus rotation model in Chau Thanh district, An Giang Province, Vietnam. We collected production data from 60 rice-lotus rotation cultivation households in the studied area through face-to-face interviews. This study used several methods, including descriptive, cost-benefit analysis, and multiple variable regression analysis. The research results showed that the rice-lotus rotation model achieved 0.81 of the profitability and investment index and 0.45 of the profitability and total income index. The total cost and income of RLR cultivation per 1,000 m² yr^-1 was 9,478,200 VND and 17,191,300 VND, respectively. Profits was 7,713,100 VND 1,000 m^-2 yr^-1. The factors that affected the financial efficiency of the RLR model included agrochemicals cost, hired labor cost for crop care, and selling price (significant level of 10%).