Vietnam and the United States are two countries with diplomatic relations many years ago. During the cold war, the Vietnam War (1961 - 1975) caused the relationship between Vietnam and the US to crack and the US had to withdraw from Vietnam in 1975. Since 1995, the two countries have resumed foreign relations and the United States has become an important country with Vietnam in economic development and has friendly diplomatic relations in all fields. The covid 19 pandemic has caused many health and life losses around the world, and vaccines are seen as the key to solving the difficulties caused by the covid 19 pandemic.Vietnam has to go through a lot of difficulties in dealing with the pandemic because of the scarcity of covid 19 vaccine resources.  In that context, the help of a covid 19 vaccine from the United States is very important and necessary. As of March 2022, the United States is the largest vaccine donor to Vietnam. This affirms that the diplomatic relations between the two countries are in the best period, especially during the period when President Joe Biden focused on Southeast Asia, including Vietnam.