This paper investigates the determinants of financial performance of shrimp processing firms in Mekong Delta. By using data collected from 35 shrimp processing firms in 11 provinces of Mekong Delta and appropriate statistical analysis, the findings showed that there are six of ten independent variables affecting on the financial performance of given firms. These are quick-liquidity ratio, payable to total liabilities, total debt to total asset, fixed asset turnover ratio, firm age and the educational level of firm head. Possible implications to improve the financial performance of the firms are related to the quick-liquidity ration and flexible capital structure of the firms.