The research has systematized the basic theoretical and practical issues of teaching Mathematics (Math) for 7th Grade students in secondary schools in Ninh Kieu District, Can Tho City, and fully surveyed the current status of Mathematics teaching activities of five secondary schools in Ninh Kieu District, Can Tho City in recent years. Based on theoretical research and practical surveys, the study would propose measures to manage these activities more effectively. Each measure has its own purpose, meaning and importance, but they all influence and interact with each other. The results of the exploration of the urgency and feasibility of the proposed measures are quite high and can be applied to practical management. It is the study that has contributed to clarifying the theoretical basis, systematizing domestic and foreign research, identifying tool concepts as a basis for theoretical research, and pointing out the theoretical content of management of Math teaching activities for 7th Graders at secondary schools in Ninh Kieu District, Can Tho City. On that basis, the research chose questionnaires for 260 respondents, including 20 administrators, 40 teachers, and 200 students at 5 secondary schools in Ninh Kieu District, Can Tho City, to get data. The research results might be applied in managing Math teaching activities for 7th-grade students in all secondary schools in Ninh Kieu District, Can Tho City. At the same time, the findings would monitor the feedback results to further evaluate the applicability of the study as a foundation for insight research and wider application into practice for secondary schools nationwide as well.