Transdisciplinary research is a type of research that involves the collaboration and integration of multiple disciplines and sectors to address complex and multifaceted problems. In the context of global health, transdisciplinary research is taking control since most of the planet's challenges, such as climate change, environmental degradation, and pandemics, are profoundly interconnected; and thus, a holistic approach is needed. To address global health related issues, a few holistic and multidisciplinary approaches are available among which One Health, EcoHealth, and Planetary Health are the most popular ideas at present. As they all support the basic presumption that humans and other living animals share the same planet and face the same environmental issues, all techniques and methodological approaches to achieve final goal may seem interchangeable. However, the newly coined term “Planetary Health” has revolutionized the subject orientation. As reviewed, transdisciplinary research is essential in addressing the complex and multifaceted challenges facing the planet and its inhabitants. For us, the issue is not which of the three holistic approaches – One Health, EcoHealth, or Planetary Health – is more applicable to sustainable development. Instead, the debate is whether the ideas and associated frameworks of One, Eco and Planetary Health should stand as autonomous solutions to the complex nature of global health, as defined by the 2030 agenda for sustainable development, or if it is better to aspire for a growing literature confluence and a broader and stronger commitment to interdisciplinary and transdisciplinary activities around the SDGs. By bringing together experts from multiple disciplines and sectors, transdisciplinary research allows a more comprehensive and holistic approach to understand these challenges, resulting in optimal effective and sustainable solutions. As such, transdisciplinary research will continue to be a vital component of efforts to promote global health and address the many challenges facing our planet.