The study applied protection motivation theory to assess the awareness and respones to cope with flood risk from farmers in the Vietnamese Mekong Delta. Data from the study were collected by interviewing 431 farmers directly in three provinces and city, including An Giang province, Hau Giang province and Can Tho city. The results from descriptive statistical methods showed that most of farmers have awareness and a high resilience against flood risk. The cognitive risk assessment for flood risk showed that about 35.03% of farmers were aware of flood risks. Farmers have also taken measures to cope with flood risks such as building solid houses, raising the floor higher than flood levels, finding weather information, preparing food storage facilities, etc. The results showed that farmers were not subjective of the risks of floods and always found out the annual information of flood situation to actively response when floods occured. However, due to the constraints of their income, farmers difficultly applied the measures of response.