Responsible tourism is the future trend of the tourism industry to achieve economic, social, and environmental sustainability goals in the destination. Loyalty of visitors is one of the factors that play a decisive role in the rapid and sustainable development of tourism. This study was conducted to analyze the impact of responsible tourism on tourist loyalty. The study sample consisted of 160 observations. Scale reliability testing, exploratory factor analysis, and multivariate regression analysis were used to process the data. Research results show that responsible tourism in Kien Hai district is constituted by responsible community action, responsible dining operation, responsible tourism product development, responsible accommodation operation, and responsible tourism communication. These factors have a decreasing influence on tourist loyalty. This study contributes to knowledge and management implications for responsible tourism development.