This paper is aimed at introducing a new dynamic and smart campus architecture based on spatial data infrastructure and distributed ontology. This architecture helps to integrate and connect between a spatial infrastructure and multiple available IT systems implemented and operated on one or multiple university campuses. This novel architecture of smart campuses will become the core of a smart digital infrastructure using for campus governance, it will answer the question of how to monitor multiple real-time activities and to integrate the spatial and non-spatial aspects inside a campus (e.g. a university or a hospital). Distributed ontology is the theoretical principle of architecture where SOA and spatial data infrastructure become the key technologies to implement the whole system. Web Features Services (WFS) is used to publish the spatial objects when different Domain-based Web Services (DWS) are used to publish the non-spatial ones. Big data can be considered as one kind of DWS to accelerate the performance and specialized data analysis of the system. Several scenarios implemented for the Can Tho University are also introduced to illustrate the components of the architecture.