This study aims to prepare in manganese ferrite/graphene oxide (MnFe₂O₄/GO) nanocomposites for the removal of ibuprofen drug residue from water. The synthesised nanocomposites with various MnFe₂O₄ content from 30–60 wt.% were characterised by X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, vibrating sample magnetometer, Brunauer - Emmett - Teller specific surface area, and energy dispersive X-ray. It was found that the suitable mass ratio of MnFe₂O₄ in nanocomposite for ibuprofen removal was 50 wt.%. The adsorption process followed the pseudo-second-order kinetic and Langmuir isotherm model. The maximum capacity of MnFe₂O₄/GO was found to be 156.25 mg g⁻¹. Accordingly, the MnFe₂O₄/GO could be used as an efficient adsorbent for the removal of ibuprofen from water.