Medicinal mushrooms are known and used to be nutraceuticals for centuries to enhance health benefits as well as to treat several diseases. Among them, Ganoderma Lucidum (i.e.: G. Lucidum, or red Reishi, or Lingzhi) is appreciated as a medicinal mushroom or significant herbal food for treating diseases, extending life and developing drug. It is detected in different locations, likely contributed confusing concerning its classification. Concomitantly, it has utilized as tea, in alcoholic drinking, and as a complementary medicine to bestow numerous health benefits. Thereby, it is truly important to identify chemical constituents and provide its activities in health benefits regarding these products. Herein, we hope that it is likely a good and right approach for utilizing and encouraging this product, as well as its advantages will be shortly summarized in disease treatments.