This paper generalize several of scientific and real values of Ho Chi Minh’s thought which lots of students have received them after they learned that major under the great effect of Industry 4.0 that creates big influences in the graduate education all over Vietnam society. So, teaching political sciences’ major and Ho Chi Minh’s thought has a lot of opportunities and threats for developing. Having to analyze the trends of Industry 4.0, writers show how to increase the quality teaching Ho Chi Minh’s thought in Can Tho University.