Article info.

ABSTRACT

Received 10 Oct 2017
Revised 02 Feb 2018

Accepted 20 Jul 2018

The derivatives of 1,4-dihydropyridines are well known as calcium channel modulators for the treatment of cardiovascular disorders. Herein, three 1,4-dihydropyridines were synthesized through the condensation of an aldehyde, a β-ketoester, and ammonium acetate in ethanol with yields ranging from 23 to 59%. Their structures were confirmed by comparison HRMS, NMR spectral data with the literature. The acute oral toxicity study for the synthesized compounds revealed that all compounds were safe up to 2,000 mg/kg, and no deaths of animals were recorded.

Keywords

1,4-dihydropyridines, acute toxicity, Hantzsch ester, β-ketoester

Cited as: Nhu, H., Yen, T.H. and Tram, N.T.T., 2018. Synthesis and acute toxicity evaluation of Hantzsch 1,4-dihydropyridine derivatives. Can Tho University Journal of Science. 54(5): 77-80.