A majority of Can Tho City’s population who live in rural districts rely on groundwater for domestic and agricultural use. Groundwater wells in this area can commonly access to the Pleistocene aquifers, at the depth of about 80-120 meters. However, groundwater quality in Can Tho City has been worsened due to industrial, urban and rural pollutants and saltwater intrusion. Groundwater depletion causes decrease in water level as well. To assess the quantity and quality of groundwater over space and time, groundwater monitoring network was established across the city, in total of 34 national monitoring wells. In this study, the main questions of concern are that whether the current groundwater monitoring network is at the most efficiency and whether more monitoring wells should be added or there are already more wells than required. Geostatistical approach was applied in this study to evaluate the efficiency of the current groundwater monitoring network by using the error in mapping as a measure of efficiency. The results show that the current groundwater monitoring network is not mostly efficient for monitoring groundwater quality and water level over the city. Extra wells should be added to the current monitoring network to improve the efficiency.