An Giang is a province of diverse terrain in the Mekong Delta, with a rich agricultural ecosystem. At present, climate change has been affecting the agricultural production of the province. This study used the methods such as: PRA, farmer interview, multi-criteria evaluation (MCE) combined with geographic information system (GIS) tool to build vulnerability maps in Agricultural production of An Giang province. The results of this study was built vulnerability mapping (droughts, floods, and salinity intrusion) at different levels of vulnerability for An Giang province. The study were established 40 vulnerabilities for different types of agricultural land use in An Giang province with different levels of impact in the current context. From the attribute database and research space data was a basis of science, to support for managers in setting agricultural development orientation and propose solutions to limit the impact of physical factors affecting to agricultural production. The results showed that the integration of GIS and MCE in building vulnerability mapping were highly feasible and achieved certain successes in the study area about space and time.