Municipal solid waste (MSW) in Vietnam has been increasing quickly and became one of the most considered environmental problems in Mekong Delta (MD) region covering 13 provinces and municipalities in the south of Vietnam. With a considerably large amount of MSW, the region produces about 5% of the total amount of MSW of the country. The collection rate of solid waste is about quite high (65 - 72%) in the cities and rather low (about 40 - 55%) in the rural areas, with a high content in organic matter (about 60 - 85%). The climate of MD can be characterized as tropical and monsoonal with a high rate of humidity and a strong impact of flooding. Like other regions too, the MSW collection and treatment system is still underdeveloped and rudimentary, with disposal sites being the sole dumping method of the unsorted MSW remaining untreated by any mechanical and biological pre-treatment steps. Within this paper, the current treatment, management and operation of MSW systems are introduced, as well as the identification of advantages and dis-advantages, environmental impacts, potential risks of the MSW system within the impact of global climate change. The situation of MSW treatment and management is correlated with the climate change impact and the integrated solid waste management is introduced as a new approach for adapting the environmental protection awareness by considering the climate change for the long-term sustainable development orientation.