Cultural tourism has always been a trend throughout the ages. Tourists' intentions to revisit are one of the indicators reflecting the sustainability of cultural tourism destinations. Investigating the relationship between these two factors can provide valuable insights for various stakeholders. This study aims to analyze the factors of a cultural tourism destination that influence tourists' intention to return, focusing on a significant cultural tourism destination in the Mekong Delta region of Vietnam. The research employs reliability testing of measurement scales, exploratory factor analysis, and multivariate linear regression with a sample size of 120 observations, yielding several noteworthy findings. A cultural tourism destination is composed of factors such as local residents, cultural attractions, tourism infrastructure, tourism service quality, tourism safety, and perceived service pricing. All these factors have significant and positive impacts on tourists' intention to revisit. Among these influencing factors, local residents, tourism safety, perceived service pricing, and tourism infrastructure have a stronger impact on tourists' intention to return compared to the other two factors.