Glochidion littorale Blume belongs to the family Phyllanthaceae, is a tropical shrub that grows wild throughout Vietnam and is found in the mangroves of Southeast Asia. In traditional medicine, this species has been applied to treat stomach ache and dysentery. However, there is not much information about chemical composition and bioactivity of this species. This study focuses on the isolation and identification of compounds from G. littorale. The methanol extract of the G.
littorale stem bark was separated by liquid-liquid extraction, followed by different chromatographic techniques to purify the chemical composition. The result showed that seven terpenoids including lupeol (1), 3-epi-lupeol (2), betulin (3), lup-20(29)-ene-1β,3β-diol (4), lupenone (5), glochidonol (6) and glochidone (7) were isolated from the methanol extract. The
chemical structures of these terpenoids were elucidated based on NMR and MS spectral analysis, and by comparison with previous references. These compounds have not been previously isolated from G. littorale.