In this study, the half-life is the time required for the thermoluminescence intensity to drop to half of its initial value. The half-life is a characteristic of the optical and thermal properties of the material. The half-life of the thermoluminescence signals under other models such as first order kinetics, second order kinetics, general order kinetics, mixed order kinetics and the one-trap one-recombination was calculated. The specific goals of this work are to give the half-life difference of the thermoluminescence signal of each model by using Python. The formulas allow to quickly determine the half-life of the simulated or empirical thermoluminescence curve, including one or more complex peak. Simulation results and calculations based on the figure of merit parameters allow to check the calculation of the half-life according to the most suitable model.