Hexaconazole has been so far reported to show several properties in plant growth regulations. This study was conducted to evaluate the enhancement of hexaconazole on the growth, yield and quality of three purple sweet potato varieties (Ipomoea batatas (L.) Lam.) in Mekong Delta. The experiment layout was randomized completely block design, in factorial arrangement with three replications. Three purple sweet potato varieties used in the experiment were HL491 from Vietnam and two varieties imported from Japan (Lord) and Malaysia. Hexaconazole of 0, 10, 15, and 100 mg/L (farmers’ practice) were spayed at 40, 55, and 70 days after planting (DAP). The results showed that the fresh vine biomass/m² and the anthocyanin content of the HL491 variety were the highest, but the number of marketable tuberous roots and total tuberous yield were lower than the two imported varieties. Hexaconazole application inhibited some agronomical characteristics such as the total leaf area, internodal and leaf petiole length at 60 DAP and reduced the fresh vine biomass (kg/m²) at harvest. The highest marketable tuberous quantity, 21 tuberous roots/m², was achieved when spraying hexaconazole at 15 mg/L while the marketable tuberous yield and anthocyanin content were 26 tons/ha and 16.2 mg/100g fresh weight (FW) equivalent to CGE, respectively. These values were higher than those counterparts of the control: 15 tuberous roots/m²; 8.05 tons/ha and 13.4 mg CGE/100 g FW.