Article info.

ABSTRACT

Received 15 Jan 2018
Revised 25 May 2018

Accepted 30 Nov 2018

The core structure of ethyl 4-acetoxy-6,8-dimethoxynaphthalene-2-carboxylate was successfully synthesized via a two-step sequence including Stobbe condensation followed by cyclization from 2,4-dimethoxybenzaldehyde as the starting material. The ethyl ester moiety was then hydrolyzed to form the corresponding carboxylic acid which was subsequently in situ converted to carboxyl choride by reacting with thionyl chloride and then to carboxamides derivatives by treating with 4-methylbenzylamine and 3-morpholinopropylamine. The structures of the synthesized compounds were fully confirmed based on MS, ¹H-NMR, ¹³C-NMR and DEPT spectroscopy data. Cytotoxicity evaluation showed that the two prepared napthalenecarboxamide derivatives had weak cytotoxicity against Lu cells and moderate cytotoxicity against Hep-G2 cell lines.

Keywords

Carboxamides, cytotoxicity, naphthalene, Stobbe reaction

Cited as: Hue, B.T.B., Luong, D.H. and Huy, H.M., 2018. Synthesis and cytotoxicity evaluation of naphthalenecarboxamide derivatives. Can Tho University Journal of Science. 54(8): 138-142.