Reduce, reuse and recycle (3Rs) is one of the elements contributing to the success oflaunching the integrated solid waste management recommended by the United Nations Environment Program. A survey of 360 urbanand suburban household respondents wasconducted in the Mekong Delta, Vietnam to understand how domestic solid waste managed athousehold level, to experience respondents’ knowledge, awareness and their acceptanceparticipating 3Rs program if it is introduced in the Mekong Delta. Results show that 78%respondents sold recyclable waste and listed activities meaning reducing, reusing and recyclingsolid domestic waste. More than 70% respondents supported this program when it is launched.The results of the logit model reveal the significant difference in factors affecting urban and suburban respondents’ acceptance this program. Age, gender and educational attainment ofrespondents, household income, respondents’ knowledge on reduce, reuse and recycle their solid domestic waste and community participation are factors affecting household acceptance involving in 3Rs. They also propose how to organize successful 3Rs program, namely thecollaboration between household and local community in organizing this program, upgradinghouseholds’ awareness on environmental protection and the support in propaganda of local authorities and social media.