This investigation studied the co-digestion between pig manure (PM) and spent mushroom compost (SMC) to produce biogas in lab-scale. The batch and semi-continuous anaerobic digesters were applied to co-digest PM+SMC with different mixing ratios based on organic dry matter values. The result of the 35 continuous day batch treatment showed that the more percentage of SMC contained in the mixing ratio of PM+SMC, the less biogas was produced but it was not significantly different between the treatments of 100%PM+0%SMC, of 75%PM+25%SMC, of 50%PM+50%SMC and of 25%PM + 75%SMC. The semi-continuous testing in 90 continuous days of 75%PM+25%SMC showed the relatively stable operation of the treatment. The outcomes indicated that farmers in the Mekong Delta can apply SMC as an additional feeding material to biogas digesters in case pig manure is short.