Objective: Applying the Technology Acceptance Model (TAM), the conducted research aims to demonstrate the factors influencing the acceptance of tourism apps among Generation Z in Vietnam. Method: The quantitative research method was employed to test the research hypotheses: Step 1: Testing the reliability of the measurement scale using Cronbach’s alpha coefficient; Step 2: Exploratory Factor Analysis (EFA) to assess the convergent and discriminant validity; Step 3: Confirmatory Factor Analysis (CFA) to evaluate the suitability of the data; Step 4: Structural Equation Modeling (SEM) to test the research hypotheses. The research data were collected using a quota sampling method, with a sample size of 246 Generation Z travelers. Results: By applying the Structural Equation Modeling (SEM), the study has shown that perceived ease of use, perceived usefulness, and attitude positively influence the intention to use tourism apps among Generation Z. The research results contribute to affirming the relevance of the Technology Acceptance Model (TAM) in the context of travel technology research. Conclusions: The results provide a useful reference for technology managers in the tourism industry and researchers studying technology acceptance.