Bitter leaf is a medicinal plant widely used in folk medicine but little studied for the biological effects. Antioxidant activities of stem extracts include n-hexane; chloroform; ethyl acetate; n-butanol; ethanol; and water, determined by the free radicals reduction ability 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and Fe³⁺ reduction capacity test. On the DPPH model with the best EC₅₀ values of Ethyl acetate and n-butanol, the EC₅₀ values were 63.73µg/mL and 87.21µg/mL. On the Fe³⁺ reduction test model with the best EC₅₀ being Ethyl acetate, the EC₅₀ value was 72.02µg/mL. Bitter leaf is a plant with the potential for antioxidant capacity and hepatoprotective bioactivity.