This study examined the challenges of learning English-American literature for English majors at Can Tho University (CTU), Vietnam. The study aimed to answer the two questions, which are the difficulties encountered by English majors and their suggested solutions to improve their learning of British-American literature/literary. The target audience was 100 English majors who have studied English-American literary works at CTU, Vietnam. A questionnaire and an interview were used to collect data for this study. A questionnaire was used to support quantitative data while an interview was used for the qualitative method. This study hoped to find out the students’ difficulties, thereby proposing solutions to overcome and improve the quality of students' literary studies