Can Tho City - a biggest city in the Mekong Delta of Vietnam - has experienced rapid urbanization in recent years. It is also to deal with substantial water and climate change challenges ranging from urban to suburban areas, as well as surface water pollution. This paper calculated the Vietnamese Water Quality Index (WQI) values based on the database of water quality monitoring stations in Can Tho City in five years. Then the QGIS software and the Inverse Distance Weighted tool were applied to map out the surface water quality spatial distribution. The calculation results showed slightly temporal and spatial variation in water quality with WQI values range from 76 to 91 which indicate good condition. The lower WQI values recorded in the dry season and at the areas where concentrate more residential zones and industry factories. The spatial interpolate result showed the good condition of water quality through a thematic and visual map. The surface water quality map could use not only by scientists but also local authorities or decision makers.